Alan D Irvine Selected Research

Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris)

6/2016	Review of Critical Issues in the Pathogenesis of Atopic Dermatitis.
5/2009	Filaggrin in the frontline: role in skin barrier function and disease.
5/2009	A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.
5/2008	Filaggrin mutations, atopic eczema, hay fever, and asthma in children.
5/2007	Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.
8/2006	Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis.
7/2006	Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
6/2006	Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis.
3/2006	Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.

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Alan D Irvine Research Topics

Disease

50	Atopic Dermatitis (Atopic Eczema) 05/2022 - 04/2006
14	Eczema 05/2022 - 03/2007
11	Asthma (Bronchial Asthma) 11/2018 - 06/2006
10	Inflammation (Inflammations) 01/2022 - 10/2008
9	Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris) 06/2016 - 03/2006
6	Dermatitis 05/2022 - 10/2013
4	Ichthyosis (Xeroderma) 01/2018 - 10/2002
3	Food Hypersensitivity (Food Allergy) 11/2018 - 02/2013
3	Psoriasis (Pustulosis Palmaris et Plantaris) 11/2010 - 08/2007
2	Alopecia (Baldness) 01/2021 - 02/2009
2	Iron Deficiencies 01/2021 - 01/2017
2	Alopecia Areata 01/2021 - 07/2020
2	Warts (Wart) 11/2020 - 05/2008
2	Allergic Rhinitis 11/2018 - 02/2013
2	Vitamin D Deficiency 03/2018 - 01/2017
2	Weight Gain 01/2018 - 11/2016
2	Hypersensitivity (Allergy) 11/2015 - 10/2013
2	Peanut Hypersensitivity (Peanut Allergy) 07/2013 - 03/2011
2	Skin Diseases (Skin Disease) 02/2013 - 05/2008
1	Hemangioma (Angioma) 06/2022
1	COVID-19 01/2021
1	Acne Vulgaris 01/2021
1	Headache (Headaches) 01/2021
1	Lipomatosis 01/2021
1	Nasopharyngitis 01/2021
1	Necrosis 01/2021
1	Neoplasms (Cancer) 01/2021
1	Obesity 01/2021
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2021
1	Proteus Syndrome 01/2021
1	Rare Diseases (Rare Disease) 01/2021
1	Hemimegalencephaly 01/2021
1	Molluscum Contagiosum 11/2020
1	Virus Diseases (Viral Diseases) 11/2020
1	Jacobsen Distal 11q Deletion Syndrome 11/2020
1	Vascular Malformations 01/2020
1	Peritonitis 01/2020
1	Cryopyrin-Associated Periodic Syndromes 01/2020
1	Cardiomyopathies (Cardiomyopathy) 01/2018
1	Dysbiosis 01/2018
1	Long Term Adverse Effects 01/2018
1	Neuroinflammatory Diseases 01/2018
1	Infections 10/2017

Drug/Important Bio-Agent (IBA)

45	Filaggrin ProteinsIBA 01/2020 - 03/2006
6	CytokinesIBA 01/2022 - 04/2012
6	Proteins (Proteins, Gene)FDA Link 02/2014 - 02/2002
5	Immunoglobulin E (IgE)IBA 01/2018 - 02/2002
4	AllergensIBA 04/2016 - 10/2008
4	Keratins (Keratin)IBA 01/2011 - 01/2005
3	dupilumabIBA 05/2022 - 07/2021
3	Immunosuppressive Agents (Immunosuppressants)IBA 07/2021 - 01/2018
3	IronIBA 01/2021 - 01/2017
3	Vitamin D FDA LinkGeneric 11/2018 - 01/2017
2	Ferritins (Ferritin)IBA 01/2021 - 01/2018
2	Cidofovir (Vistide)FDA Link 11/2020 - 05/2008
2	InflammasomesIBA 01/2020 - 10/2019
2	hydroxide ionIBA 11/2018 - 01/2017
2	Desmoplakins (Desmoplakin)IBA 01/2018 - 11/2015
2	Interleukin-1 (Interleukin 1)IBA 11/2016 - 04/2012
2	Desmoglein 1IBA 11/2015 - 10/2013
2	Small Interfering RNA (siRNA)IBA 05/2014 - 01/2011
2	Biological ProductsIBA 09/2009 - 10/2008
2	Serine Peptidase Inhibitor Kazal-Type 5IBA 09/2008 - 02/2002
1	Propranolol (Inderal)FDA LinkGeneric 06/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022
1	LipidsIBA 01/2022
1	MiransertibIBA 01/2021
1	upadacitinibIBA 01/2021
1	Janus Kinase InhibitorsIBA 01/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021
1	Androgen Antagonists (Antiandrogens)IBA 01/2021
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2021
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2021
1	Sirolimus (Rapamycin)FDA Link 01/2021
1	Therapeutic UsesIBA 01/2021
1	Janus KinasesIBA 01/2021
1	TYK2 Kinase (Tyrosine Kinase 2)IBA 01/2021
1	Uric Acid (Urate)IBA 01/2020
1	itaconic acidIBA 01/2020
1	Interleukin-18 (Interleukin 18)IBA 01/2020
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	Interleukin-17 (Interleukin 17)IBA 10/2019
1	Interleukin-13IBA 10/2019
1	Interleukin-4 (Interleukin 4)IBA 10/2019
1	Interleukin-22 (IL-22)IBA 10/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2019
1	Interleukin-9 (Interleukin 9)IBA 10/2019
1	Interleukin-5 (Interleukin 5)IBA 10/2019
1	VaccinesIBA 01/2019
1	25-hydroxyvitamin DIBA 11/2018
1	IodineIBA 01/2018
1	SpectrinIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Ustekinumab (CNTO 1275)FDA Link 01/2018

Therapy/Procedure

14	Therapeutics 05/2022 - 09/2013
2	Immunomodulation 01/2021 - 01/2017
1	Cesarean Section (Caesarean Section) 01/2021
1	Catheters 01/2021
1	Phototherapy (Light Therapy) 10/2017